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VX-661

A CFTR modulator
Catalog #: B1268
SKU-Size Size Price Qty
B1268-5 5 mg
$115.00
B1268-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide; Tezacaftor
Appearance Crystaline solid
CAS # 1152311-62-0
Molecular Formula C₂₆H₂₇F₃N₂O₆ 
Molecular Weight 520.5
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(CO)C1=CC2=CC(=C(C=C2N1CC(CO)O)F)NC(=O)C3(CC3)C4=CC5=C(C=C4)OC(O5)(F)F
InChi InChI=1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1
InChi Key MJUVRTYWUMPBTR-MRXNPFEDSA-N
PubChem CID 46199646
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VX-661, is CFTR modulator that is potentially useful for treatment of cystic fibrosis.  VX-661 corrects F508del-CFTR trafficking and increases F508del-CFTR protein activity in vitro.


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