VU0361737

A positive allosteric modulator at mGlu4 receptors
Catalog #: 9418 | abID:

Product Details

Alternate Name N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Appearance Off-white solid
CAS # 1161205-04-4
Molecular Formula C₁₃H₁₁ClN₂O₂
Molecular Weight 262.69
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
InChi InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
InChi Key ARYUXFNGXHNNDM-UHFFFAOYSA-N
PubChem CID 44191096
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.


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