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VS-5584

A potent and selective PI3K/mTOR kinase inhibitor
Catalog #: 9603
SKU-Size Size Price Qty
9603-1 1 mg
$85.00
9603-5 5 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine; SB2343
Appearance Crystalline solid
CAS # 1246560-33-7
Molecular Formula C₁₇H₂₂N₈O
Molecular Weight 354.41
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N
InChi InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)
InChi Key QYBGBLQCOOISAR-UHFFFAOYSA-N
PubChem CID 46912230
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VS-5584 is a potent and selective PI3K/mTOR kinase inhibitor. It inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. Also acts as a cancer stem cell inhibitor


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