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VR23

A potent and selective proteasome inhibitor
Catalog #: B1515
SKU-Size Size Price Qty
B1515-5 5 mg
$135.00
B1515-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 7-chloro-4-(4-((2,4-dinitrophenyl)sulfonyl)piperazin-1-yl)quinoline
Appearance Yellow solid
CAS # 1624602-30-7
Molecular Formula C₁₉H₁₆ClN₅O₆S 
Molecular Weight 477.88
Purity ≥98% by HPLC
Solubility DMSO (~ 0.5 mg/ml)
SMILES C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=C(C=C(C=C4)[N+](=O)[O-])[N+](=O)[O-]
InChi InChI=1S/C19H16ClN5O6S/c20-13-1-3-15-16(11-13)21-6-5-17(15)22-7-9-23(10-8-22)32(30,31)19-4-2-14(24(26)27)12-18(19)25(28)29/h1-6,11-12H,7-10H2
InChi Key PDQVZPPIHADUOO-UHFFFAOYSA-N
PubChem CID 73442847
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

VR23 is a potent and selective inhibitor of trypsin-like proteasomes (IC₅₀ = 1 nmol/L), chymotrypsin-like proteasomes (IC₅₀ = 50-100 nmol/L), and caspase-like proteasomes (IC₅₀ = 3 μmol/L). The main molecular target of VR23 was β2 of the 20S proteasome catalytic subunit. It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.


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