Product Details
| abID | ab52323 |
|---|---|
| Alternate Name | PBEF, Pre-B cell colony-enhancing factor, Nicotinamide phosphoribosyltransferase NAmPRTase, Nampt, MGC117256, DKFZP666B131, 1110035O14Rik. |
| Gene Symbol | NAMPT |
| Gene ID | 10135 |
| Accession # | P43490 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized with no additives. |
| Molecular Weight | 55.0 kDa |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | <0.1 ng/μg |
| Reconstitution Instructions | Reconstitute in PBS to the concentration of 0.1-1 mg/ml. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Visfatin exerts insulin-mimetic effects that are dose-dependent and quantitatively similar to those of insulin in stimulating muscle and adipocyte glucose transport, and in inhibiting hepatocyte glucose production. Intravenous injection of recombinant visfatin in mice decreased plasma glucose in a dose-dependent fashion. In keeping with its insulin-mimetic effects, visfatin was as effective as insulin in reducing hyperglycemia in insulin-deficient diabetic mice. Visfatin was also found to be bound to and activate insulin receptor, causing receptor phosphorylation and the activation of downstream signaling molecules. However, visfatin and insulin did not compete for binding to the insulin receptor, indicating that the two proteins were recognized by different regions of the receptor. Thus, visfatin might play a role in glucose homeostasis and dysregulation in biosynthesis or signal transduction, and might contribute to the pathogenesis of diabetes.
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Horbal, Steven R. et al. (2016) Associations of Apelin, Visfatin, and Urinary 8-Isoprostane With Severe Hypertension in African Americans: The MH-GRID Study. Am J Hypertens. 2016 Jul;29(7):814-20.
Ladislav Senolt, et. al. Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis, Nov 2011; 70: 2054 - 2056.
Senolt, S. et. al. Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. Ann Rheum Dis, May 2011; 10.1136/ard.2011.152603.
Xia, M. et. al. Membrane raft–lysosome redox signalling platforms in coronary endothelial dysfunction induced by adipokine visfatin. Cardiovasc Res, Feb 2011; 89: 401 - 409.
Xia, M., et al.Membrane Raft-Lysosome Redox Signalling Platforms in Coronary Endothial Dysfunction Induced by Adipokine Visfatin. Cardiovasc. Res., 2010; 10.1093/cvr/cvq286.
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