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Vinblastine Sulfate

A tubulin polymerrization inhibitor

WARNING: This product can expose you to chemicals including Vinblastine, which is [are] known to the State of California to cause birth defects or other reproductive harm.  For more information go to  www.P65Warnings.ca.gov.
Catalog #: 1959
SKU-Size Size Price Qty
1959-5 5 mg
$80.00
1959-25 25 mg
$305.00
More Sizes Get Quote

Product Details

Alternate Name Vincaleukoblastine sulfate salt; VLB
Appearance White solid
CAS # 143-67-9
Molecular Formula C₄₆H₅₈N₄O₉S.H₂SO₄
Molecular Weight 909.05
Purity ≥95% by HPLC
Solubility DMSO (~ 50 mg/ml) or Water (~ 10 mg/ml)
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
InChi InChI=1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1
InChi Key KDQAABAKXDWYSZ-JKDPCDLQSA-N
PubChem CID 241902
MDL Number MFCD00082457
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule assembly and causes aberrant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent.


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