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VEGI/TL1 human recombinant

An anti-angiogenic protein
Catalog #: 4966
SKU-Size Size Price Qty
4966-10 10 μg
$295.00
4966-50 50 μg
$895.00
4966-1000 1 mg
$6,950.00
More Sizes Get Quote

Product Details

Alternate Name Tumor necrosis factor ligand superfamily member 15, TNFSF-15, TNFSF15, TNF ligand-related molecule 1, VEGI, TL-1, TL1, TL1A, VEGI192A, VEGI-192, MGC129934, MGC129935, Vascular endothelial cell growth inhibitor.
Gene Symbol TNFSF15
Gene ID 41019336
Accession # AAR98573
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized from a solution containing 0.5 M NaCl, 50 mM Tris-HCl, pH 7.5.
Molecular Weight 21.8 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent inhibition of the proliferation of HUVEC is <5 ug/ml.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1–1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

VEGI (Vascular Endothelial Growth Inhibitor) is a member of the tumor necrosis factor family. VEGI is predominantly an endothelial cell-specific gene, and recombinant VEGI is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. VEGI exerts two activities of endothelial cells: early Gl arrest of G0/G1-cells responding to growth stimuli, and programmed cell death. VEGI is also able to regulate the expression of several important genes involved in angiogenesis. Human VEGF is a 21.8 kDa homodimeric protein consisting of 192 amino acid polypeptide chains.


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