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VEGFR2, human recombinant

based on 1 citations in multiple journalsVEGFR2, human recombinant14.1 4
Receptor for VEGF
Catalog #: 4952
SKU-Size Size Price Qty
4952-10 10 μg
$240.00
4952-100 100 μg
$1,705.00
More Sizes Get Quote

Product Details

Alternate Name Fetal liver kinase 1, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1
Gene Symbol VEGFR2
Gene ID 3791
Accession # P35968
Source Insect cells
Appearance Lyophilized protein
Physical Form Description KDR was lyophilized from a sterile solution containing 25 mM MES pH 5.5 and 100 mM NaCl.
Molecular Weight 116 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity The activity of VEGFR2 D1-7 was determined by its ability to abolish the binding of iodinated VEGF to solid surfaces or cell surfaces receptors. The ED50 for this effect is typically 10.0 ng/ml, corresponding to a specific activity of 100,000IU/mg.
Reconstitution Instructions Reconstitute in sterile water to a concentration not less than 0.1 mg/ml. This solution can then be stored at 4°C for 2-7 days. For future use for future use; For long term storage it is recommended to add a carrier protein (0.1 % HSA or BSA) then store a
Amino Acid Sequence ASVGLPSVSL DLPRLSIQKD ILTIKANTTL QITCRGQRDL DWLWPNNQSG SEQRVEVTEC SDGLFCKTLT IPKVIGNDTG AYKCFYRETD LASVIYVYVQ DYRSPFIASV SDQHGVVYIT ENKNKTVVIP CLGSISNLNV SLCARYPEKR FVPDGNRISW DSKKGFTIPS YMISYAGMVF CEAKINDESY QSIMYIVVVV GYRIYDVVLS PSHGIELSVG EKLVLNCTAR TE
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signaling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. No naturally occurring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin. Soluble VEGFR-2 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide having a molecular mass of 116 kDa. The soluble receptor protein contains only the first 7 extracellular domains, which contain all the information necessary for ligand binding. The sKDR is purified by proprietary chromatographic techniques.


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Crispin T. Hiley et al., Vascular Endothelial Growth Factor A Promotes Vaccinia Virus Entry into Host Cells via Activation of the Akt Pathway. J. Virol., Mar 2013; 87: 2781 - 2790.
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