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VEGFR-2 & tubulin inhibitor

A dual VEGFR-2 and tubulin inhibitor
Catalog #: B2932
SKU-Size Size Price Qty
B2932-5 5 mg
$85.00
B2932-25 25 mg
$325.00
More Sizes Get Quote

Product Details

Alternate Name (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine; Dual VEGFR-2 and tubulin inhibitor
Appearance Solid
CAS # 830333-53-4
Molecular Formula C₂₂H₁₉N₅O₃
Molecular Weight 401.42
Purity 95%
Solubility Soluble in DMSO
SMILES C1(NC2=CC=C(OCCO3)C3=C2)=NN=C(C4=CC=CC=C4NCC5=CC=NC=C5)O1
InChi InChI=1S/C22H19N5O3/c1-2-4-18(24-14-15-7-9-23-10-8-15)17(3-1)21-26-27-22(30-21)25-16-5-6-19-20(13-16)29-12-11-28-19/h1-10,13,24H,11-12,14H2,(H,25,27)
InChi Key IQVQCEHRAJVTIU-UHFFFAOYSA-N
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing G2/M arrest in A431 cells. Mice treated with this inhibitor show less toxicity and normal pathology.


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