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VEGFR-2 inhibitor

An inhibitor of VEGFR-2
Catalog #: B2938
SKU-Size Size Price Qty
B2938-1 1 mg
B2938-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name 4-((2-((4-Chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide
Appearance Solid
CAS # 769960-39-6
Molecular Formula C₂₆H₂₆ClN₅O₄
Molecular Weight 507.97
Purity 95%
Solubility Soluble in DMSO
SMILES O=C(C1=NC=CC(OC2=CC=C(OC(NC3=CC=C(Cl)C(OC[[email protected]]4N(C)CCC4)=C3)=N5)C5=C2)=C1)NC
InChi InChI=1S/C26H26ClN5O4/c1-28-25(33)22-14-19(9-10-29-22)35-18-6-8-23-21(13-18)31-26(36-23)30-16-5-7-20(27)24(12-16)34-15-17-4-3-11-32(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,28,33)(H,30,31)/t17-/m0/s1
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat corneal angiogenesis model.

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