VEGF121, human recombinant

A signaling protein involved in both vasculogenesis and angiogenesis
Catalog #: 4963 | abID:

Product Details

Alternate Name Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGF, MGC70609.
Gene Symbol VEGFA
Gene ID 7422
Accession # P15692
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized with no additives
Molecular Weight 28.4 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity Determined by the dose-dependent stimulation of the proliferation of human μmbilical vein endothelial cells (HUVEC) using a concentration range of 0.1-0.5 ng/ml.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

VEGF (Vascular Endothelial Growth Factor) is a secreted homodimeric protein, secreted by a variety of Vascularized tissues. VEGF stimulates endothelial cell growth, angiogenesis, and capillary permeability. Human VEGF is a 28.4 kDa homodimeric protein consisting of two 121 amino acid polypeptide chains.


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Caballero, S. et. al.  Selective Blockade of Cytoskeletal Actin Remodeling Reduces Experimental Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci., Apr 2011; 52: 2490 - 2496.
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