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VEGF-D, human recombinant

A protein involved in angiogenesis, lymphangiogenesis and endothelial cell growth and survival
Catalog #: 4643
SKU-Size Size Price Qty
4643-10 10 μg
$185.00
4643-50 50 μg
$595.00
4643-1000 1 mg
$4,850.00
More Sizes Get Quote

Product Details

Alternate Name Vascular Endothelial Growth Factor-D, FIGF, c-Fos-induced growth factor
Gene Symbol FIGF
Gene ID 2277
Accession # O43915
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized without additives
Purity by SDS-PAGE ≥98%
Endotoxin Level <0.1 ng/μg
Reconstitution Instructions Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. Recombinant VEGF-D was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.


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