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VEGF-D Antibody

Catalog #: 5643
SKU-Size Size Price Qty
5643-30T 30 µg
$89.00
5643-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target VEGF-D
Alternate Name VEGF-D Polyclonal Antibody, Anti-VEGF-D antibody, VEGF-D antibody, Anti-VEGF-D, VEGF-D, VEGF D
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen E. coli expressed human VEGF-D
Accession # D89630
Gene ID 2277
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 30 µg (0.5 mg/ml) affinity purified rabbit anti- VEGF-D polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.
Purification Affinity purified
Species Reactivity Human
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Recombinant human VEGF-D (Cat.# 4643-10) can be used as a positive control. Other applications have not been determined.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

EGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. The recombinant VEGF-D as the immunogen was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.


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