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VEGF-C, human recombinant

based on 5 citations in multiple journalsVEGF-C, human recombinant54.1 4
A protein involved in angiogenesis, lymphangiogenesis and endothelial cell growth and survival
Catalog #: 4633
SKU-Size Size Price Qty
4633-10 10 μg
$195.00
4633-50 50 μg
$495.00
4633-1000 1 mg
$2,850.00
More Sizes Get Quote

Product Details

Alternate Name Vascular Endothelial Growth Factor-C, VEGFC, Flt4 ligand
Gene Symbol VEGFC
Gene ID 7424
Accession # Q6FH59
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives
Molecular Weight 15-16 kDa
Purity by SDS-PAGE ≥90%
Endotoxin Level <0.1 ng/μg
Biological Activity Activity of VEGF-C is tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED₅₀ is > 200 ng/ml.
Reconstitution Instructions Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

The recombinant VEGF-C (Vascular Endothelial Growth Factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with murine VEGF-C.


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Zhou, H. et. al. Exogenous VEGF-C Augments the Efficacy of Therapeutic Lymphangiogenesis Induced by Allogenic Bone Marrow Stromal Cells in a Rabbit Model of Limb Secondary Lymphedema. Jpn. J. Clin. Oncol., Jul 2011; 41: 841 - 846.
Zhou, h. et. al. Exogenous VEGF-C Augments the Efficacy of Therapeutic Lymphangiogenesis Induced by Allogenic Bone Marrow Stromal Cells in a Rabbit Model of Limb Secondary Lymphedema. Jpn. J. Clin. Oncol., May 2011; 10.1093/jjco/hyr055.
Argaw AT et al (2009) PNAS; 106: 1977 - 1982.
Jackowski S et al. (2007) Am. J. Pathol. 171: 338-348.
Agraw, A.T., et al. (2006) J. Immunol. 177: 5574-5584.
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