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VEGF-B, human recombinant

Involved in maintenance of newly formed blood vessels during pathological conditions
Catalog #: 4642
SKU-Size Size Price Qty
4642-20 20 μg
$185.00
4642-100 100 μg
$495.00
4642-1000 1 mg
$3,450.00
More Sizes Get Quote

Product Details

Alternate Name Vascular Endothelial Growth Factor-B, VEGFB, VEGF-related factor
Gene Symbol VEGFB
Gene ID 7423
Accession # P49765
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized without additives
Molecular Weight 19.63 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity Per researcher’s feedback, the protein is biologically active as determined by the dose-dependent stimulation of the proliferation of human μmbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED₅₀ for this effect is 0.5
Reconstitution Instructions Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.


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