Product Details
| Alternate Name | Vascular Endothelial Growth Factor-B, VEGFB, VEGF-related factor |
|---|---|
| Gene Symbol | VEGFB |
| Gene ID | 7423 |
| Accession # | P49765 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized without additives |
| Molecular Weight | 19.63 kDa |
| Purity by SDS-PAGE | ≥98% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | Per researcher’s feedback, the protein is biologically active as determined by the dose-dependent stimulation of the proliferation of human μmbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED₅₀ for this effect is 0.5 |
| Reconstitution Instructions | Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, regulates angiogenesis and Vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
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