VCAM-1/CD106 Antibody (Center)

Polyclonal Antibody to detect VCAM1 in human and mouse samples.
Catalog #: 6783 | abID:

Product Details

Cat # +Size 6783-100
Size 100 μl
Antibody Target VCAM1
Alternate Name VCAM1; L1CAM; Vascular cell adhesion protein 1; INCAM-100
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen This CD106 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human CD106.
Accession # P19320
Gene ID 7412
Appearance Colorless liquid
Formulation In PBS with 0.09% (W/V) sodium azide.
Purification Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Species Reactivity Human, Mouse.
Application Western blot.
Positive Control Western blot: NIH-3T3 and HepG2 cell lysates.
Application & Usage WB: 1:1000.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell adhesion molecules are a family of closely related cell surface glycoproteins involved in cell-cell interactions during growth and are thought to play an important role in embryogenesis and development. Neuronal cell adhesion molecule (NCAM) expression is observed in a variety of human tumors including neuroblastoma, rhabdomyosarcoma, Wilms’ tumors, Ewing’s sarcomas and some primitive myeloid malignancies. The intracellular adhesion molecule-1 (ICAM-1), also referred to as CD54, is an integral membrane protein of the immunoglobulin superfamily and recognizes the B2å1 and B2åM integrins. PECAM-1 (platelet/endothelial cell adhesion molecule-1), also referred to as CD31, is a glycoprotein expressed on the cell surfaces of monocytes, neutrophils, platelets and a subpopulation of T cells. VCAM-1 (vascular cell adhesion molecule-1) was first identified as an adhesion molecule induced on human endothelial cells by inflammatory cytokines such as IL-1, tumor necrosis factor (TNF) and lipopolysaccharide (LPS). The KALIG gene encodes a nerve cell adhesion molecule (NCAM) -like protein and is deleted in 66% of patients with Kallmann's syndrome, anosmia with secondary hypogonadism.


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