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Varlitinib

A potent EGFR family inhibitor
Catalog #: 2656
SKU-Size Size Price Qty
2656-5 5 mg
$155.00
2656-25 25 mg
$620.00
More Sizes Get Quote

Product Details

Alternate Name (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine
Appearance White solid
CAS # 845272-21-1
Molecular Formula C₂₂H₁₉ClN₆O₂S
Molecular Weight 466.94
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1COC(=N1)NC2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=NC=CS5)Cl
InChi InChI=1S/C22H19ClN6O2S/c1-13-10-31-22(27-13)29-14-2-4-18-16(8-14)21(26-12-25-18)28-15-3-5-19(17(23)9-15)30-11-20-24-6-7-32-20/h2-9,12-13H,10-11H2,1H3,(H,27,29)(H,25,26,28)/t13-/m1/s1
InChi Key UWXSAYUXVSFDBQ-CYBMUJFWSA-N
PubChem CID 42642648
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Varlitinib is a potent inhibitor of the epidermal growth factor receptor (EGFR) family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone.


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