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USP7/USP47 Inhibitor, P 22077

A USP7/USP47 inhibitor
Catalog #: 2301
SKU-Size Size Price Qty
2301-5 5 mg
2301-25 25 mg
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Product Details

Alternate Name 1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone; DUB inhibitor
Peptide Sequence No
Appearance Yellow solid
CAS # 1247819-59-5
Molecular Formula C₁₂H₇F₂NO₃S₂
Molecular Weight 315.32
Purity ≥98% by HPLC
Solubility DMSO (~ 30 mg/ml)
SMILES FC1=CC(F)=CC=C1SC2=C([N+]([O-])=O)C=C(C(C)=O)S2
InChi InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A cell-permeable inhibitor of the ubiquitin-specific protease (IC₅₀ = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀>50 µM) towards a panel of 14 isopeptidases and other proteases. Inhibits USP7-mediated p53 deubiquitination.

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