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USP5 Antibody

Polyclonal antibody to detect USP5 (a DUB enzyme) in human samples.
Catalog #: 6132
$145.00

Product Details

Cat # +Size 6132-50
Size 50 μg
Antibody Target USP5
Alternate Name Deubiquitinating enzyme 5, Isopeptidase T, IsoT, ISOT, Ubiquitin carboxyl-terminal hydrolase 5, Ubiquitin-specific-processing protease 5, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5.
Host Chicken
Antibody Type Polyclonal
Isotype Chicken IgG
Immunogen Recombinant full length protein
Accession # P45974
Gene ID 8078
Appearance Colorless liquid
Formulation 50 µg of antibody in PBS containing 10% glycerol
Purification Purified from egg yolk
Species Reactivity Human
Application Western blot
Application & Usage Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP5 (ubiquitin specific peptidase 5), also known as ISOT (isopeptidase T), is a 858 amino acid zinc-binding deubiquitinating enzyme that participates in the Ub pathway. A member of the peptidase C19 family, the catalytic activity of USP5 involves a combination of the ubiquitin carboxyl-terminal thiolester and water to produce ubiquitin and a thiol. USP5 contains two UBA domains and one UBP-type zinc finger. USP5 is responsible for disassembling unanchored polyubiquitin chains in the cell. Full length USP5 mediated cleavage of Ub-PLA2 is significantly enhanced is enhanced by low concentrations of mono ubiquitin.


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