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Product Details
| Cat # +Size | 6136-50 |
|---|---|
| Size | 50 μg |
| Antibody Target | USP34 Core |
| Alternate Name | FLJ43910, KIAA0570, KIAA0729, Ubiquitin Specific Protease 34 core domain. |
| Host | Chicken |
| Antibody Type | Polyclonal |
| Isotype | Chicken IgG |
| Immunogen | Recombinant full length protein |
| Accession # | Q70CQ2 |
| Gene ID | 9736 |
| Appearance | Colorless liquid |
| Formulation | 50 µg of antibody in PBS containing 10% glycerol |
| Purification | Purified from egg yolk |
| Species Reactivity | Human |
| Application | Western blot |
| Application & Usage | Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
USP34 Core is a ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. It acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. It recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. It is involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. Its catalytic core consists of residues 1892-2241.
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