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USP25 Antibody

Polyclonal antibody to detect USP25 (a DUB enzyme) in human, mouse and rat samples.
Catalog #: 6143
$335.00

Product Details

Cat # +Size 6143-100
Size 100 μg
Antibody Target USP25
Alternate Name USP25, USP21
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Fusion protein of human USP25
Accession # Q9UHP3
Gene ID 29761
Appearance Colorless liquid
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Positive Control Western Blot: BxPC-3 cell lysate
Application & Usage Western blot: 1:500 – 1:1000 dilution. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzymes (DUB) action. There are five DUB subfamilies including the USP, UCH, OTU, MJD, and JAMM enzymes. USP25 (ubiquitin specific peptidase 25), also known as USP21, is a 1087 amino acid member of the peptidase C19 family. Expressed at high amounts in pancreas, kidney, skeletal muscle, testis, liver, heart, brain and lung, USP25 associates with the 26S proteasome and functions as a deubiquitinating enzyme in the Ub proteolytic pathway. Due to alternative splicing events, USP25 is expressed as two short, ubiquitously expressed isoforms and one long, muscle specific isoform. The long isoform of USP25 is upregulated in myogenesis and is implicated in the pathogenesis of severe myopathies.


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