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USP2 Antibody

Polyclonal antibody to detect USP2 (a DUB enzyme) in human, mouse and rat samples.
Catalog #: 6141
$335.00

Product Details

Cat # +Size 6141-100
Size 100 μg
Antibody Target USP2
Alternate Name USP2, UBP41, USP9
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Fusion protein of human USP2
Accession # O75604
Gene ID 9099
Appearance Colorless liquid
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot, Immunohistochemistry, Immunofluorescence
Positive Control Western Blot: Liver cell lysate
Application & Usage Western blot: 1:200 – 1:500 dilution, IHC: 1:50 - 1:100 dilution. IF: 1:20 - 1:50 dilution. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ubiquitinating enzymes (UBEs) catalyze protein ubiquitination, a reversible process countered by deubiquitinating enzymes (DUB) action. There are five DUB subfamilies including the USP, UCH, OTU, MJD, and JAMM enzymes. Ubiquitin­specific­processing protease 2 (USP2) belongs to the USP (UBP/UCH type 2) subfamily and is characterized by its C19 peptidase activity, which is involved in ubiquitin recycling and in the disassembly of various forms of polymeric ubiquitin and ubiquitin like protein complexes. There is mounting evidence that USP2 functions as an oncoprotein through multiple mechanisms. In human prostate cancer, USP2 is highly overexpressed and drives tumor growth by binding to and stabilizing fatty acid synthase through deubiquitination. It has also been demonstrated that USP2 can bind and deubiquitinate both Mdm2 and cyclin D1, which leads to their stabilization and enhanced cell proliferation.


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