USP14 Inhibitor, IU1

A USP14 inhibitor
Catalog #: 1845 | abID: ab142122

Product Details

abID ab142122
Alternate Name 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone
Appearance White to off-white solid
CAS # 314245-33-5
Molecular Formula C₁₈H₂₁FN₂O
Molecular Weight 300.37
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
InChi InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3
PubChem CID 675434
MDL Number MFCD01917473
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC₅₀ = 4-5 µM). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34 μM.

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