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Product Details
| Alternate Name | Two chain urokinase-type plasminogen activator (tcuPA), PLAU, ATF, UPA, URK, u-PA, BDPLT5，QPD |
|---|---|
| Gene Symbol | PLAU |
| Gene ID | 5328 |
| Accession # | P00749 |
| Source | E. coli. |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized from proprietary buffer. |
| Molecular Weight | The active Urokinase is a two-chain glycoprotein and has a calculated MW of 49.3 kDa. DTT-reduced Protein migrates as two bands corresponding to the two chains with the molecular mass of 28.3 and 21 kDa. |
| Purity by SDS-PAGE | ≥90% |
| Biological Activity | >1500 mU/mg (1 U = Digestion of 1 µmole of Z-GGR-AMC substrate in 1 min at 37ºC.) |
| Reconstitution Instructions | Briefly spin down the vial and reconstitute in water to 0.5-1 mg/ml and store at –80°C. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Urokinase or Urokinase-type plasminogen activator (uPA) is a serine protease (EC 3.4.21.73). It is secreted as a single-chain zymogen, pro-Urokinase, possessing little or no intrinsic enzymatic activity. The single chain zymogen is converted into the active two chain enzyme (tcuPA) by cleavage of the bond between Lys158 and Ile159. After activation, Urokinase specifically cleaves the proenzyme plasminogen to form the active enzyme plasmin. The active plasmin then catalyzes the breakdown of fibrin polymers of blood clots. Urokinase is involved in a number of biological functions including fibrinolysis, embryogenesis, cell migration, tissue remodeling, ovulation, and wound healing. Additionally, it is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.
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