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uPAR Antibody

based on 1 citations in multiple journalsuPAR Antibody14.1 4
Catalog #: 3440

In stock

$295.00

Product Details

Cat # +Size 3440-100
Size 100 µg
Antibody Target uPAR
Host Goat
Antibody Type Polyclonal
Isotype Goat IgG
Immunogen E. coli expressed recombinant human uPAR
Accession # Q03405
Gene ID 5329
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation 100 µg (0.5 mg/ml) purified goat polyclonal antibody in 1X phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal..
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunoprecipitation, Neutralization
Application & Usage Western blotting (0.5-2 µg/ml), immunoprecipitation (5-10 µg/ml), and neutralization (2-4 µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 55 kDa human uPAR. Reactivity to other species has not been te
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

uPAR (Urokinase plasminogen activator receptor) is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator (uPA). Upon binding to uPAR, uPA converts the surface bound, large serum β-globulin, plasminogen to plasmin. Plasmin, which is also designated fibrinolysin, is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen, and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.


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Viswanathan K et al (2009) J. Leukoc. Biol.; 85: 418 - 426.
For more citations of this product click here
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