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UNC2170

A ligand for the Methyl-lysine Binding Protein, 53BP1.
Catalog #: 2889
SKU-Size Size Price Qty
2889-5 5 mg
$145.00
2889-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide
Appearance Off-white solid
Molecular Formula C₁₄H₂₁BrN₂O
Molecular Weight 313.23
Purity ≥98% by HPLC
Solubility DMSO
SMILES BrC1=CC(C(NCCCNC(C)(C)C)=O)=CC=C1
InChi InChI=1S/C14H21BrN2O/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18)
InChi Key XUFUVCIZFNREBI-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UNC-2170 is a micromolar ligand for the Methyl-lysine Binding Protein, 53BP1. UNC-2170 displays 17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. It functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.


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