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Product Details
| Alternate Name | 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide |
|---|---|
| Appearance | Off-white solid |
| Molecular Formula | C₁₄H₂₁BrN₂O |
| Molecular Weight | 313.23 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | BrC1=CC(C(NCCCNC(C)(C)C)=O)=CC=C1 |
| InChi | InChI=1S/C14H21BrN2O/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18) |
| InChi Key | XUFUVCIZFNREBI-UHFFFAOYSA-N |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
UNC-2170 is a micromolar ligand for the Methyl-lysine Binding Protein, 53BP1. UNC-2170 displays 17-fold selectivity for 53BP1 as compared to other methyl-lysine (Kme) binding proteins tested. It functions as a 53BP1 antagonist in cellular lysates and shows cellular activity by suppressing class switch recombination, a process which requires a functional 53BP1 tudor domain.
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