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UNC1999

A potent EZH2 methyltransferase inhibitor
Catalog #: 2449
SKU-Size Size Price Qty
2449-5 5 mg
$135.00
2449-25 25 mg
$540.00
More Sizes Get Quote

Product Details

Alternate Name 1-Isopropyl-6-(6-(4-isopropylpiperazin-1-yl)pyridin-3-yl)-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-1H-indazole-4-carboxamide
Appearance White to off-white solid
CAS # 1431612-23-5
Molecular Formula C₃₃H₄₃N₇O₂
Molecular Weight 569.74
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES CC1=CC(CCC)=C(CNC(C2=C(C=NN3C(C)C)C3=CC(C4=CN=C(N5CCN(C(C)C)CC5)C=C4)=C2)=O)C(N1)=O
InChi InChI=1S/C33H43N7O2/c1-7-8-24-15-23(6)37-33(42)28(24)19-35-32(41)27-16-26(17-30-29(27)20-36-40(30)22(4)5)25-9-10-31(34-18-25)39-13-11-38(12-14-39)21(2)3/h9-10,15-18,20-22H,7-8,11-14,19H2,1-6H3,(H,35,41)(H,37,42)
InChi Key DPJNKUOXBZSZAI-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent histone H3-lysine 27 (H3K27) methyltransferase EZH2 inhibitor (IC₅₀ = 2 nM). UNC1999 is >1000-fold selective for other HMTs except EZH1 (22-fold selectivity). It inhibits H3K27 methylation in MCF10A cells with an IC₅₀ of 124 nM as measured by immunofluorescence.


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