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UNC0646

A potent G9a inhibitor
Catalog #: 2606
SKU-Size Size Price Qty
2606-5 5 mg
$135.00
2606-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name N-​(1-​cyclohexyl-​4-​piperidinyl)-​2-​[hexahydro-​4-​(1-​methylethyl)-​1H-​1,​4-​diazepin-​1-​yl]-​6-​methoxy-​7-​[3-​(1-​piperidinyl)propoxy]-​4-​quinazolinamine
Appearance Pale yellow solid
CAS # 1320288-17-2
Molecular Formula C₃₆H₅₉N₇O₂
Molecular Weight 621.9
Purity >98% by HPLC
Solubility DMSO (~50 mg/ml) or EtOH (~50 mg/ml)
SMILES CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6
InChi InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)
InChi Key OUKWLRHRXOPODD-UHFFFAOYSA-N
PubChem CID 53315882
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.


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