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UNC0642

A potent and selective and potent G9a and GLP inhibitor
Catalog #: 2862
SKU-Size Size Price Qty
2862-5 5 mg
$145.00
2862-25 25 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Appearance White solid
CAS # 1481677-78-4
Molecular Formula C₂₉H₄₄F₂N₆O₂
Molecular Weight 546.7
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F
InChi InChI=1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)
InChi Key RNAMYOYQYRYFQY-UHFFFAOYSA-N
PubChem CID 53315878
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UNC0642 is a potent, selective and cell-permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone lysine methyltransferases. UNC0642 exhibits an in vitro IC₅₀ <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC₅₀ = 106 nM.


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