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Apotent G9a HMTase inhibitor
Catalog #: 1933
SKU-Size Size Price Qty
1933-1 1 mg
1933-5 5 mg
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Product Details

Alternate Name 2-​Cyclohexyl-​6-​methoxy-​N-​[1-​(1-​methylethyl)-​4-​piperidinyl]-​7-​[3-​(1-​pyrrolidinyl)propoxy]-​4-​quinazolinamine
Appearance Off-white solid
CAS # 1255580-76-7
Molecular Formula C₃₀H₄₇N₅O₂
Molecular Weight 509.72
Purity ≥98% by HPLC
Solubility DMSO (10 mM)
InChi InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
PubChem CID 46224516
MDL Number MFCD17215972
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC₅₀ value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC₅₀ value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC₅₀ value of 81 nM and demonstrates favorable separation of functional and toxic effect.

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