Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

UNC0638

Apotent G9a HMTase inhibitor
Catalog #: 1933
SKU-Size Size Price Qty
1933-1 1 mg
$80.00
1933-5 5 mg
$205.00
More Sizes Get Quote

Product Details

Alternate Name 2-​Cyclohexyl-​6-​methoxy-​N-​[1-​(1-​methylethyl)-​4-​piperidinyl]-​7-​[3-​(1-​pyrrolidinyl)propoxy]-​4-​quinazolinamine
Appearance Off-white solid
CAS # 1255580-76-7
Molecular Formula C₃₀H₄₇N₅O₂
Molecular Weight 509.72
Purity ≥98% by HPLC
Solubility DMSO (10 mM)
SMILES CC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)C5CCCCC5
InChi InChI=1S/C30H47N5O2/c1-22(2)35-17-12-24(13-18-35)31-30-25-20-27(36-3)28(37-19-9-16-34-14-7-8-15-34)21-26(25)32-29(33-30)23-10-5-4-6-11-23/h20-24H,4-19H2,1-3H3,(H,31,32,33)
InChi Key QOECJCJVIMVJGX-UHFFFAOYSA-N
PubChem CID 46224516
MDL Number MFCD17215972
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC₅₀ value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC₅₀ value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC₅₀ value of 81 nM and demonstrates favorable separation of functional and toxic effect.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.