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UNC0379

A selective, substrate-competitive inhibitor of the lysine methyltransferase SET8
Catalog #: 9588
SKU-Size Size Price Qty
9588-5 5 mg
$125.00
9588-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 6,7-dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
Appearance Crystalline solid
CAS # 1620401-82-2
Molecular Formula C₂₃H₃₅N₅O₂
Molecular Weight 413.56
Purity ≥98% by HPLC
Solubility DMSO (~20 mg/ml)
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCCC3)NCCCCCN4CCCC4)OC
InChi InChI=1S/C23H35N5O2/c1-29-20-16-18-19(17-21(20)30-2)25-23(28-14-8-9-15-28)26-22(18)24-10-4-3-5-11-27-12-6-7-13-27/h16-17H,3-15H2,1-2H3,(H,24,25,26)
InChi Key WEXCGGWTIDNVNT-UHFFFAOYSA-N
PubChem CID 78357767
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SET8 (IC₅₀ = 7.3 µM; Kd = 18.3 µM). It is selective for SET8 over 15 other methyltransferases, including G9a and GLP (IC₅₀s = >100 µM).


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