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A G9a Histone Methyltransferase inhibitor
Catalog #: B2823
SKU-Size Size Price Qty
B2823-1 1 mg
B2823-5 5 mg
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Product Details

Alternate Name 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine; N-Debenzyl-N-methyl-O-demethyl-O-(3-dimethylaminopropyl)-BIX 01294; 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine; Histone Lysine Methyltransferase Inhibitor V
Appearance Crystalline solid
CAS # 1197196-48-7
Molecular Formula C₂₆H₄₃N₇O₂
Molecular Weight 485.67
Purity ≥98%
Solubility ~2.5 mg/ml in PBS, pH 7.2
~15 mg/ml in Ethanol
~2 mg/ml in DMSO and DMF
InChi InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29)
PubChem CID 44251522
MDL Number MFCD18251564
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


UNC0224 is a selective G9a Histone Methyltransferase inhibitor. G9a methylates Histone H3 lysine 9, which is required for early embryogenesis. UNC0224 inhibits G9a with an IC₅₀ of 15 nM. It also inhibits GLP, another H3K9 methyltransferase with an IC₅₀ of 20 nM.

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