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UNC-669

A MBT domain antagonist
Catalog #: 2620
SKU-Size Size Price Qty
2620-5 5 mg
$85.00
2620-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone)
Appearance Pale orange yellow solid
CAS # 1314241-44-5
Molecular Formula C₁₅H₂₀BrN₃O
Molecular Weight 338.24
Purity >98% by HPLC
Solubility DMSO (~15 mg/ml)
SMILES O=C(C1=CC(Br)=CN=C1)N2CCC(N3CCCC3)CC2
InChi InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2
InChi Key CQERVFFAOOUFEQ-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UNC-669 is a small molecule nicotinamide derivative that acts asan antagonist of the MBT(Malignant Brain Tumor) domain, a family of methyl-lysine binding reader proteins. UNC669 displays selectivity for L3MBTL3 (IC₅₀ = 3.1 µM) and L3MBTL1(IC₅₀ = 4.2 µM) over L3MBTL4 (IC₅₀ = >10 µM).


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