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UNC 1215

A potent L3MBTL3 domain inhibitor
Catalog #: 2252
SKU-Size Size Price Qty
2252-1 1 mg
$65.00
2252-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name (2-​(Phenylamino)-​1,​4-​phenylene)bis((4-​(pyrrolidin-​1-​yl)piperidin-​1-​yl)methanone
Appearance White to Off-white Solid
CAS # 1415800-43-9
Molecular Formula C₃₂H₄₃N₅O₂
Molecular Weight 529.72
Purity ≥98% by HPLC
Solubility DMSO (50 mM)
SMILES C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=C(C=C3)C(=O)N4CCC(CC4)N5CCCC5)NC6=CC=CC=C6
InChi InChI=1S/C32H43N5O2/c38-31(36-20-12-27(13-21-36)34-16-4-5-17-34)25-10-11-29(30(24-25)33-26-8-2-1-3-9-26)32(39)37-22-14-28(15-23-37)35-18-6-7-19-35/h1-3,8-11,24,27-28,33H,4-7,12-23H2
InChi Key PQOOIERVZAXHBP-UHFFFAOYSA-N
PubChem CID 57339144
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptional repressors. It binds L3MBTL3 with a Kd value of 120 nM (IC₅₀ = 40 nM), competitively displacing mono- or dimethyl-lysine containing peptides. UNC1215 is > 50-fold selective toward L3MBTL3 than other members of the human MBT family and demonstrates selectivity against more than 200 other Kme reader domains examined.


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