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An inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L
Catalog #: B2848
SKU-Size Size Price Qty
B2848-1 1 mg
B2848-5 5 mg
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Product Details

Alternate Name N-tert-butyl-2-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]imidazo[1,2-a]pyrazin-3-amine; N-(1,1-dimethylethyl)-2-[4-(3,5-dimethyl-4-isoxazolyl)phenyl]-imidazo[1,2-a]pyrazin-3-amine
Appearance A crystalline solid
CAS # 1635437-39-6
Molecular Formula C₂₁H₂₃N₅O
Molecular Weight 361.44
Purity ≥98%
Solubility ~20 mg/ml in ethanol and DMF
~10 mg/ml in DMSO
InChi InChI=1S/C21H23N5O/c1-13-18(14(2)27-25-13)15-6-8-16(9-7-15)19-20(24-21(3,4)5)26-11-10-22-12-17(26)23-19/h6-12,24H,1-5H3
PubChem CID 86208116
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


UMB-32 is an inhibitor of the BET bromodomain BRD4 and the bromodomain-containing transcription factors TAF1 and TAF1L. UMB-32 binds BRD4 with a Kd of 550 nM and the EC₅₀ is 724 nM in BRD4-dependent lines. UMB-32 binds to TAF1 and TAF1L with the Kd values of 560 nM and 1.3 μM, respectively.

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