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UHRF1 Antibody

Polyclonal antibody to detect UHRF1 in human samples.
Catalog #: 6144
$335.00

Product Details

Cat # +Size 6144-100
Size 100 μg
Antibody Target UHRF1
Alternate Name FLJ21925, ICBP90, MGC138707, Np95, RNF106, hNP95
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Recombinant protein of human UHRF1
Accession # Q96T88
Gene ID 29128
Appearance Colorless liquid
Concentration 1 mg/ml
Formulation 100 µg of antibody in 100 µl PBS containing 0.02% sodium azide, 50% glycerol, pH 7.3
Purification Affinity purified
Species Reactivity Human
Application Western blot, Immunohistochemistry, Immunoprecipitation, Immunofluorescene, CHIP
Positive Control Western Blot: Various cell lysates
Application & Usage Western blot: 1:500 – 1:2000, IHC: 1:50 – 1:200, IF: 1:20 – 1:50, IP: 1:20 – 1:50, CHIP: 1:20 – 1:50. However, the optimal conditions should be determined individually.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

UHRF1, also named as ICBP90, NP95 and RNF106, is a putative E3 ubiquitin protein ligase. It may participate in methylation dependent transcriptional regulation. UHRF1 binds to inverted 5'­CCAAT­3' box 2 in the TOP2A promoter, and activates TOP2A expression. It is important for G1/S transition and may be involved in DNA repair and chromosomal stability. UHRF1's ability to repress its direct target gene expression is dependent on PHD (UHRF1) binding to unmodified H3R2.


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