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UCHL1 Antibody

Polyclonal antibody to detect UCHL1 (a DUB enzyme) in human samples.
Catalog #: 6130
$145.00

Product Details

Cat # +Size 6130-50
Size 50 μg
Antibody Target UCHL1
Alternate Name Neuron cytoplasmic protein 9.5, PARK5, PGP9.5, PGP 9.5, Ubiquitin carboxyl-terminal, hydrolase isozyme L1, Ubiquitin thioesterase L1, UCH-L1, Ubiquitin thioesterase L1.
Host Chicken
Antibody Type Polyclonal
Isotype Chicken IgG
Immunogen Recombinant full length protein
Accession # P09936
Gene ID 7345
Appearance Colorless liquid
Formulation 50 µg of antibody in PBS containing 10% glycerol
Purification Purified from egg yolk
Species Reactivity Human
Application Western blot
Positive Control Western Blot: Crude HEK293 cell lysate
Application & Usage Western blot: Robust detection of 100 ng of recombinant protein was possible when antibody was used at a final concentration of 5 μg/mL
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Protein ubiquitination and Deubiquitination are reversible processes catalyzed by ubiquitinating enzymes (UBEs) and deubiquitinating enzymes (DUBs). DUBs are categorized into 5 subfamilies: USP, UCH, OTU, MJD, and JAMM. UCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all possess a conserved catalytic domain (UCH domain) of about 230 amino acids. Although UCHL1 and UCHL3 are the most closely related UCH family members with about 53% identity, their biochemical properties differ in that UCHL1 binds monoubiquitin and UCHL3 shows dual specificity toward both ubiquitin (Ub) and NEDD8, a Ub-like molecule. UCHL1 (PGP9.5) is a 25 kDa protein; it is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It comprises >1% of total brain protein but is almost absent from other tissues. It has been implicated both in Parkinson’s disease and in lung cancer.


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