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Ubiquitin-AMC

An industry standard substrate for deubiquitinylating enzymes (DUBs)
Catalog #: 4842
$235.00

Product Details

Cat # +Size 4842-25
Size 25 μg
Alternate Name Ubiquitin-Aminomethylcoumarin
Appearance Liquid
Physical Form Description A solution in DMSO ( 1 mg/ml)
Molecular Weight 8.6 Kda
Purity by ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Prepared by the C-terminal derivatisation of ubiquitin with 7-amino-4-methylcoumarin. Acts as a useful and sensitive fluorogenic substrate for a wide range of deubiquitinylating enzymes (DUBs), including ubiquitin C-terminal hydrolases (UCHs) and ubiquitin specific proteases (USPs). Ubiquitin-AMC has been shown to be a sensitive substrate for UCH-L3 (Km = 0.039μM) and for Isopeptidase-T (Km = 0.17-1.4μM), as well as for studying deubiquitinylating activity where detection sensitivity or continuous monitoring of activity is essential.


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