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Ubiquitin Aldehyde, human recombinant

An inhibitor of deubiquitinylating enzymes (DUBs)
Catalog #: 4845

In stock

$365.00

Product Details

Cat # +Size 4845-50
Size 50 μg
Alternate Name Ubiquitin Aldehyde
Source E. coli
Appearance Liquid
Physical Form Description In 50 mM NaOAc pH 5.0
Molecular Weight 8.6 kDa
Purity by >97% Pure active Recombinant human Ubiquitin Aldehyde.
Biological Activity UCHL3 activity with Ubiquitin-AMC measured in the presence of 17.5 nM and 0.1 nM Ubiquitin Aldehyde.
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

The C-terminal glycine carboxyl of Ubiquitin is synthetically modified to an aldehyde. Ubiquitin Aldehyde (Ub-H) is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. Inhibition of deubiquitinylating enzyme activity by Ub-H can be used to identify and confirm such activity and to determine the inhibition kinetics for a particular enzyme. Recommended concentration for maximal inhibition is 2-5 µM. Co-crystallization of ubiquitin aldehyde with specific deubiquitinylating enzymes (the inhibitor mimics the natural ubiquitin substrate) has also been used to probe enzyme:substrate interactions.


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