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UbcH5c, human recombinant (His-tag)

An essential ubiquitin-conjugating enzyme
Catalog #: 4854
$350.00

Product Details

Cat # +Size 4854-100
Size 100 μg
Alternate Name UbcH5c, Ubiquitin conjugating enzyme H5c, Ubiquitin conjugating enzyme, Ubiquitin carrier protein D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, Ubiquitin-protein ligase D3
Gene Symbol UB2D3
Gene ID 7323
Accession # P61077
Source E. coli
Appearance Liquid
Physical Form Description Supplied at a concentration of 1.0 mg/ml in 20 mM Tris-HCl, pH 7.5, containing 0.5 mM DTT.
Molecular Weight 17.0 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

UbcH5c is highly homologous to the S. cerevisiae UbC4/5 family of E2 enzymes, demonstrated to be essential for degradation of regulatory and abnormal proteins. UbcH5c, together with UbcH5a and UbcH5b, are the most active class of E2 enzymes in cell extracts and are associated with regulation of a number of transcription factors including p53. The His-tagged version of this enzyme is not susceptible to self-ubiquitinylation, which can occur with GST-tagged versions. Typical enzyme concentration to support in vitro conjugation is 100 nM to 1 µM depending upon the conditions.


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