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UbcH3, human recombinant (His-tag)

An essential ubiquitin-conjugating enzyme
Catalog #: 4849

Product Details

Cat # +Size 4849-100
Size 100 μg
Alternate Name UbcH3, Ubiquitin conjugating enzyme 3, Ubiquitin conjugating enzyme, Ubiquitin-conjugating enzyme E2-32 kDa complementing, Ubiquitin-conjugating enzyme E2-CDC34, Ubiquitin-protein ligase R1, CDC34, UBCH3, UBE2R1
Gene Symbol UB2R1
Gene ID 997
Accession # P49427
Source E. coli
Appearance Liquid
Physical Form Description Supplied at a concentration of 0.5 mg/ml in 50 mM HEPES, 50 mM NaCl, pH 8.0, containing 1.0 mM DTT.
Molecular Weight 32.0 kDa
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


UbcH3 is a class II enzyme, homologous to Cdc34 from Saccharomyces cerevisiae, and is important in the control of cell cycle and DNA replication. UbcH3/Cdc34 in association with different E3 complexes, including SCF, has been shown to target many different substrates for ubiquitination and degradation during cell division, signal transduction, and development. UbcH3 substrates that have been characterized include IκB, Wee1, ICERIIγ, p27Xic1. Additionally, substrates such as ß-catenin, p21, and is phosphorylated and ubiquitinylated in vivo.

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