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U0126

based on 1 citations in multiple journalsU012614.1 4
A MEK inhibitor
Catalog #: 1668
$130.00

Product Details

Cat # +Size 1668-5
Size 5 mg
Alternate Name 1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene
Appearance White to off-white solid
CAS # 109511-58-2
Molecular Formula C₁₈H₁₆N₆S₂
Molecular Weight 380.48
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES C1=CC=C(C(=C1)N)SC(=C(C#N)C(=C(N)SC2=CC=CC=C2N)C#N)N
InChi InChI=1S/C18H16N6S2/c19-9-11(17(23)25-15-7-3-1-5-13(15)21)12(10-20)18(24)26-16-8-4-2-6-14(16)22/h1-8H,21-24H2/b17-11+,18-12+
InChi Key DVEXZJFMOKTQEZ-JYFOCSDGSA-N
PubChem CID 3006531
MDL Number MFCD01861186
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Potent and selective non-competitive inhibitor of MAP kinase kinase(MEK). Inhibits MEK-1 and MEK-2 (IC₅₀ values of 0.07 and 0.06 µM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4.


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Lee et al., Arabidopsis Putative MAP Kinase Kinase Kinases Raf10 and Raf11 are Positive Regulators of Seed Dormancy and ABA Response. Plant Cell Physiol., Jan 2015; 56: 84 - 97.
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