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TZ9

An inhibitor of Rad6B/HHR6B
Catalog #: B2835
SKU-Size Size Price Qty
B2835-1 1 mg
$65.00
B2835-5 5 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name TZ9; (4-amino-6-anilino-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate, (4-amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate; Rad6 inhibitor; HHR6 inhibitor
Appearance A crystalline solid
CAS # 1002789-86-7
Molecular Formula C₁₇H₁₄N₆O₄
Molecular Weight 366.33
Purity ≥98%
Solubility ~30 mg/ml in DMSO and DMF
SMILES C1=CC=C(C=C1)NC2=NC(=NC(=N2)N)COC(=O)C3=CC=C(C=C3)[N+](=O)[O-]
InChi InChI=1S/C17H14N6O4/c18-16-20-14(21-17(22-16)19-12-4-2-1-3-5-12)10-27-15(24)11-6-8-13(9-7-11)23(25)26/h1-9H,10H2,(H3,18,19,20,21,22)
InChi Key RRRDZFQRNJTKHL-UHFFFAOYSA-N
PubChem CID 7593228
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TZ9 is a triazine analogue inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B/HHR6B. It docks to the Rad6B catalytic site. It inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin, induces G2-M arrest and apoptosis of human breast cancer MDA-MB-231 cells. It inhibits proliferation of MDA-MB-231 cells with an IC₅₀ of 6 μM.


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