Tyrphostin AG 490

An EGFR inhibitor

Tyrphostin AG 490 is available from Abcam as ab120950.
Catalog #: 1570 | abID:

Product Details

Cat # +Size 1570-5
Size 5 mg
Alternate Name 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide; 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide, AG 490
Appearance Off-white solid
CAS # 133550-30-8
Molecular Formula C₁₇H₁₄N₂O₃
Molecular Weight 294.31
Purity ≥99%
Solubility DMSO (100 mM) and ETOH (20 mM)
InChi InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
PubChem CID 5328779
MDL Number MFCD00236452
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Selectively inhibits EGF receptor auto-phosphorylation (IC₅₀ = 100 µM) and selectively inhibits DNA synthesis and cell growth; induces apoptosis. A JAK2 inhibitor. Blocks growth of leukemia cells in vivo and in vitro.

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