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A novel S1P3 receptor antagonist
Catalog #: B1582
SKU-Size Size Price Qty
B1582-5 5 mg
B1582-25 25 mg
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Product Details

Alternate Name N-(4-Chlorophenyl)-3,3-dimethyl
Appearance Yellow solid
CAS # 934369-14-9
Molecular Formula C₁₈H₁₉Cl₂N₃O
Molecular Weight 364.27
Purity ≥98% by HPLC
Solubility DMSO (>35 mg/ml) or EtOH (>30 mg/ml)
InChi InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
PubChem CID 16046248
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.

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