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TWEAK Receptor, human recombinant

Activates cell apoptotic machinery
Catalog #: 7208
SKU-Size Size Price Qty
7208-10 10 μg
$145.00
7208-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name TNF-related weak inducer of apoptosis receptor, TNFRSF12A, FGF-inducible 14, TWEAKR
Gene Symbol TNFRSF12A
Gene ID 51330
Accession # Q9NP84
Source E. Coli
Appearance Lyophilized powder
Physical Form Description Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5 and 50 mM NaCl
Molecular Weight 5.6 kDa
Purity by SDS-PAGE ≥98%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg)
Biological Activity Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Amino Acid Sequence EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic “death domain,” which can activated the cell’s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein.


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