Product Details
| Alternate Name | Tunicamycin from Streptomyces sp. |
|---|---|
| Appearance | White solid |
| CAS # | 11089-65-9 |
| Molecular Formula | C₃₈H₆₂N₄O₆ |
| Molecular Weight | 830.93 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~40 mg/ml) or EtOH (~5 mg/ml, warm) |
| SMILES | O[[email protected]]1[[email protected]](O)[[email protected]@H](CO)O[[email protected]](O[[email protected]]2[[email protected]](NC(/C=C/CCCCCCCCCC(C)C)=O)[[email protected]@H](O)[[email protected]@H](O)[[email protected]@H](C[[email protected]@H](O)[[email protected]@H]3[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N4C=CC(NC4=O)=O)O3)O2)[[email protected]@H]1N(C(C)=O)[H] |
| InChi | InChI=1S/C38H62N4O16/c1-19(2)13-11-9-7-5-4-6-8-10-12-14-24(46)40-27-31(51)28(48)22(55-37(27)58-36-26(39-20(3)44)30(50)29(49)23(18-43)56-36)17-21(45)34-32(52)33(53)35(57-34)42-16-15-25(47)41-38(42)54/h12,14-16,19,21-23,26-37,43,45,48-53H,4-11,13,17-18H2,1-3H3,(H,39,44)(H,40,46)(H,41,47,54)/b14-12+/t21-,22-,23-,26-,27-,28+,29-,30-,31-,32+,33-,34-,35-,36-,37+/m1/s1 |
| InChi Key | MEYZYGMYMLNUHJ-DIRMKAHISA-N |
| PubChem CID | 71312646 |
| MDL Number | MFCD00065709 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
From Streptomyces lysosuperificus. Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs in the fatty acid chain. Potent inhibitor of GlcNAc phosphotransferase which thereby inhibits glycoprotein biosynthesis. Causes endoplasmic reticulum stress-induced autophagy and unfolded protein response. Arrests cell cycle in late G1.
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