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Tudor domain-containing protein 4 (hTDRD4, domain 30-139aa), human recombinant

Involved in RISC complex and interaction with AEG-1 oncogene
Catalog #: 7251
SKU-Size Size Price Qty
7251-20 20 μg
$195.00
7251-100 100 μg
$595.00
7251-1000 1 mg
$4,850.00
More Sizes Get Quote

Product Details

Alternate Name RING finger protein 17, Tudor domain-containing protein 4, TDRD4, RNF17
Gene Symbol TDRD4
Gene ID 56163
Accession # Q9BXT8
Source E. coli
Appearance Liquid
Physical Form Description 1.0 mg/ml solution in 25 mM Tris (pH 8.0) buffer containing 20% glycerol.
Molecular Weight 14.6 kDa (110 aa + NT 6 x His-tag)
Purity by SDS-PAGE ≥98%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

Tudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The Tudor domains recognize symmetric methylated arginine or methylated lysine residues. Tudor domain proteins act as an oncogene and play a very important role in HCC and colon cancer. TDRD is also involved in RISC complex and interacts with AEG-1 oncogene. The Tudor domain can bind to methylated arginine protein and promote tumor angiogenesis in human hepatocellular carcinoma, etc. TDRD4 is a candidate CT antigen expressed in a subset of liver cancers. The recombinant protein includes TDRD4 (domain 30-139 aa) with N-terminal His-tag.


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