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Tropodithietic Acid

A broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria
Catalog #: B1867

In stock

$185.00

Product Details

Cat # +Size B1867-1
Size 1 mg
Alternate Name 3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Appearance Orange solid
CAS # 750590-18-2
Molecular Formula C₈H₄O₃S₂
Molecular Weight 212.3
Purity ≥98% by HPLC
Solubility DMSO (~5 mg/ml)
SMILES C1=CC(=O)C(=C2C(=C1)SS2)C(=O)O
InChi InChI=1S/C8H4O3S2/c9-4-2-1-3-5-7(13-12-5)6(4)8(10)11/h1-3H,(H,10,11)
InChi Key BLFCMITWMARUSM-UHFFFAOYSA-N
PubChem CID 44632924
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tropodithietic acid is a broad spectrum tropolone antibiotic with activity against both Gram-negative and Gram-positive bacteria. Displays cytotoxic effects on mammalian cell lines (neuronal N2a cells and OLN-93 cells as model systems for nerve cells and glia) acting via disruption of mitochondrial membrane potential, activation of ERK1/2 and induction of HSP32/HO-1 (considered as a sensor of oxidative stress). A broad-spectrum antibiotic agent produced by marine bacteria which does not appear to induce resistance after long-term exposure.


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