Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A farnesoid X receptor agonist
Catalog #: B2603
SKU-Size Size Price Qty
B2603-1 1 mg
B2603-5 5 mg
More Sizes Get Quote

Product Details

Alternate Name LJN 452, LJN-452, LJN452, 2-[(1R,3r,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 1383816-29-2
Molecular Formula C₂₉H₂₅F₄N₃O₅S
Molecular Weight 603.59
Purity ≥98% by HPLC
Solubility in DMSO
SMILES O=C(C1=CC(F)=C2N=C(N3[[email protected]@]4([H])C[[email protected]](OCC5=C(C6CC6)ON=C5C7=CC=CC=C7OC(F)(F)F)C[[email protected]]3([H])CC4)SC2=C1)O
InChi InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24 (35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,17+,18+
PubChem CID 121418176
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Tropifexor (LJN452) is a highly potent, non-bile acid FXR (farnesoid X receptor) agonist with an EC₅₀ of 0.2 nM. Potentially useful for the treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.